Direct and Indirect Regulatory Mechanisms in TH17 cell Differentiation and Functions

被引：30

作者：

Bi, Y. ^{[1
]}

Yang, R. ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Microbiol & Epidemiol, Natl Ctr Biomed Anal,State Key Lab Pathogen & Ana, Army Ctr Microbial Detect & Res,Lab Analyt Microb, Beijing 100071, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2012年 / 75卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HUMAN DENDRITIC CELLS; ROR-GAMMA-T; TGF-BETA; BORDETELLA-PERTUSSIS; HELPER-CELLS; T(H)17 CELLS; EFFECTOR; RECEPTOR; IL-17; PATHOGENESIS;

D O I：

10.1111/j.1365-3083.2012.02686.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (TH17) cells have well-described roles in autoimmune diseases. The immune modulations of development and function of TH17 have become a key issue. In this review, we summarize the recent findings regarding the direct and indirect signalling regulatory mechanisms of TH17 cells in the general mouse model of autoimmune diseases and other human diseases.

引用

收藏

页码：543 / 552

页数：10

相关论文

共 97 条

[1] InterIeukin-23/Th17 Pathways and Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy .

INFLAMMATORY BOWEL DISEASES, 2009, 15 (07) :1090-1100

[2] IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

ANNUAL REVIEW OF MEDICINE, 2009, 60 :97-110

[3] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[4] Type 17 T helper cells-origins, features and possible roles in rheumatic disease [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Liotta, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

NATURE REVIEWS RHEUMATOLOGY, 2009, 5 (06) :325-331

[5] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[6]

Bi Y, 2010, J CELL PHYSL, V226, P8

[7] Th17 cell induction and immune regulatory effects [J].

Bi, Yujing ;

Liu, Guangwei ;

Yang, Ruifu .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (02) :273-278

[8] MicroRNAs: Novel Regulators During the Immune Response [J].

Bi, Yujing ;

Liu, Guangwei ;

Yang, Ruifu .

JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 218 (03) :467-472

[9] Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [J].

Brand, S. .

GUT, 2009, 58 (08) :1152-1167

[10] Inhibition of ERK MAPK Suppresses IL-23-and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease [J].

Brereton, Corinna F. ;

Sutton, Caroline E. ;

Lalor, Stephen J. ;

Lavelle, Ed C. ;

Mills, Kingston H. G. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (03) :1715-1723

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