Direct and Indirect Regulatory Mechanisms in TH17 cell Differentiation and Functions

被引：30

作者：

Bi, Y. ^{[1
]}

Yang, R. ^{[1
]}

机构：

[1] Acad Mil Med Sci, Inst Microbiol & Epidemiol, Natl Ctr Biomed Anal,State Key Lab Pathogen & Ana, Army Ctr Microbial Detect & Res,Lab Analyt Microb, Beijing 100071, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2012年 / 75卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HUMAN DENDRITIC CELLS; ROR-GAMMA-T; TGF-BETA; BORDETELLA-PERTUSSIS; HELPER-CELLS; T(H)17 CELLS; EFFECTOR; RECEPTOR; IL-17; PATHOGENESIS;

D O I：

10.1111/j.1365-3083.2012.02686.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (TH17) cells have well-described roles in autoimmune diseases. The immune modulations of development and function of TH17 have become a key issue. In this review, we summarize the recent findings regarding the direct and indirect signalling regulatory mechanisms of TH17 cells in the general mouse model of autoimmune diseases and other human diseases.

引用

收藏

页码：543 / 552

页数：10

相关论文

共 97 条

[51] The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus [J].

Kwan, Bonnie Ching-Ha ;

Tam, Lai-Shan ;

Lai, Ka-Bik ;

Lai, Fernand Mac-Moune ;

Li, Edmund Kwok-Ming ;

Wang, Gang ;

Chow, Kai-Ming ;

Li, Philip Kam-Tao ;

Szeto, Cheuk-Chun .

RHEUMATOLOGY, 2009, 48 (12) :1491-1497

[52] RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F [J].

Leppkes, Moritz ;

Becker, Christoph ;

Ivanov, Ivaylo I. ;

Hirth, Sebastian ;

Wirtz, Stefan ;

Neufert, Clemens ;

Pouly, Sandrine ;

Murphy, Andrew J. ;

Valenzuela, David M. ;

Yancopoulos, George D. ;

Becher, Burkhard ;

Littman, Dan R. ;

Neurath, Markus F. .

GASTROENTEROLOGY, 2009, 136 (01) :257-267

[53] T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation [J].

Li, Ming O. ;

Wan, Yisong Y. ;

Flavell, Richard A. .

IMMUNITY, 2007, 26 (05) :579-591

[54] Signals that influence T follicular helper cell differentiation and function [J].

Linterman, Michelle A. ;

Vinuesa, Carola G. .

SEMINARS IN IMMUNOPATHOLOGY, 2010, 32 (02) :183-196

[55] The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells [J].

Liu, Guangwei ;

Yang, Kai ;

Burns, Samir ;

Shrestha, Sharad ;

Chi, Hongbo .

NATURE IMMUNOLOGY, 2010, 11 (11) :1047-U103

[56] Regulation of IL-17 in human CCR6+ effector memory T cells [J].

Liu, Hong ;

Rohowsky-Kochan, Christine .

JOURNAL OF IMMUNOLOGY, 2008, 180 (12) :7948-7957

[57] AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19 [J].

Liu, Weicheng ;

Ouyang, Xinshou ;

Yang, Jianjun ;

Liu, Jianguo ;

Li, Qingshan ;

Gu, Yongpeng ;

Fukata, Masayuki ;

Lin, Tony ;

He, John Cijiang ;

Abreu, Maria ;

Unkeless, Jay C. ;

Mayer, Lloyd ;

Xiong, Huabao .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (36) :24006-24016

[58] IL-23 and IL-12p70 production by monocytes and dendritic cells in primary HIV-1 infection [J].

Louis, Stephanie ;

Dutertre, Charles-Antoine ;

Vimeux, Lene ;

Fery, Ludovic ;

Henno, Lucy ;

Diocou, Seckou ;

Kahi, Sandrine ;

Deveau, Christiane ;

Meyer, Laurence ;

Goujard, Cecile ;

Hosmalin, Anne .

JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 87 (04) :645-653

[59] Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells [J].

Lu, Ling ;

Wang, Julie ;

Zhang, Feng ;

Chai, Yang ;

Brand, David ;

Wang, Xuehao ;

Horwitz, David A. ;

Shi, Wei ;

Zheng, Song Guo .

JOURNAL OF IMMUNOLOGY, 2010, 184 (08) :4295-4306

[60] Th17 cytokines and arthritis [J].

Lubberts, Erik .

SEMINARS IN IMMUNOPATHOLOGY, 2010, 32 (01) :43-53

← 1 2 3 4 5 6 7 8 9 10 →