Designer skin: lineage commitment in postnatal epidermis

被引：164

作者：

Niemann, C ^{[1
]}

Watt, FM ^{[1
]}

机构：

[1] Canc Res UK, Keratinocyte Lab, London WC2A 3PX, England

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0962-8924(02)02263-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The epidermis is populated by stem cells that produce daughters that differentiate to form the interfollicular epidermis, hair follicles and sebaceous glands. Diffusible factors, cell-cell contact and extracellular matrix proteins are all important components of the microenvironment of individual stem cells and profoundly affect the differentiation pathways selected by their progeny. Here, we summarize what is known about stem-cell populations and lineage relationships within the epidermis. We also present evidence that postnatal epidermis can be reprogrammed, altering the number and location of cells that differentiate along specific epidermal lineages.

引用

页码：185 / 192

页数：8

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