Biologically inspired strategies for combating bacterial biofilms

被引：115

作者：

Blackledge, Meghan S. ^{[1
]}

Worthington, Roberta J. ^{[1
]}

Melander, Christian ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 05期

关键词：

C-DI-GMP; QUORUM-SENSING SIGNAL; STAPHYLOCOCCUS-AUREUS; PSEUDOMONAS-AERUGINOSA; ACINETOBACTER-BAUMANNII; EXTRACELLULAR DNA; CYCLIC DIGUANYLATE; ALGINATE LYASE; VIRULENCE; INHIBITION;

D O I：

10.1016/j.coph.2013.07.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Infections caused by bacterial biofilms are a significant global health problem, causing considerable patient morbidity and mortality and contributing to the economic burden of infectious disease. This review describes diverse strategies to combat bacterial biofilms, focusing firstly on small molecule interference with bacterial communication and signaling pathways, including quorum sensing and two-component signal transduction systems. Secondly we discuss enzymatic approaches to the degradation of extracellular matrix components to effect biofilm dispersal. Both of these approaches are based upon non-microbicidal mechanisms of action, and thereby do not place a direct evolutionary pressure on the bacteria to develop resistance. Such approaches have the potential to, in combination with conventional antibiotics, play an important role in the eradication of biofilm based bacterial infections.

引用

页码：699 / 706

页数：8

共 90 条

[21] Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening [J].

DiGiandomenico, Antonio ;

Warrener, Paul ;

Hamilton, Melissa ;

Guillard, Sandrine ;

Ravn, Peter ;

Minter, Ralph ;

Camara, Maria Margarita ;

Venkatraman, Vignesh ;

MacGill, Randall S. ;

Lin, Jia ;

Wang, Qun ;

Keller, Ashley Elaine ;

Bonnell, Jessica C. ;

Tomich, Mladen ;

Jermutus, Lutz ;

McCarthy, Michael P. ;

Melnick, David A. ;

Suzich, JoAnn A. ;

Stover, C. Kendall .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (07) :1273-1287

[22] Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes [J].

Donelli, G. ;

Francolini, I. ;

Romoli, D. ;

Guaglianone, E. ;

Piozzi, A. ;

Ragunath, C. ;

Kaplan, J. B. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (08) :2733-2740

[23]

Dong YH, 2005, J MICROBIOL, V43, P101

[24] AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora [J].

Dong, YH ;

Xu, JL ;

Li, XZ ;

Zhang, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3526-3531

[25] Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase [J].

Dong, YH ;

Wang, LH ;

Xu, JL ;

Zhang, HB ;

Zhang, XF ;

Zhang, LH .

NATURE, 2001, 411 (6839) :813-817

[26] Biofilms: Microbial life on surfaces [J].

Donlan, RM .

EMERGING INFECTIOUS DISEASES, 2002, 8 (09) :881-890

[27] Development of an Antivirulence Drug against Streptococcus mutans: Repression of Biofilm Formation, Acid Tolerance, and Competence by a Histidine Kinase Inhibitor, Walkmycin C [J].

Eguchi, Yoko ;

Kubo, Norihiro ;

Matsunaga, Hiroko ;

Igarashi, Masayuki ;

Utsumi, Ryutaro .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (04) :1475-1484

[28] Quorum sensing: A novel target for anti-infective therapy [J].

Finch, RG ;

Pritchard, DI ;

Bycroft, BW ;

Williams, P ;

Stewart, GSAB .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (05) :569-571

[29] The biofilm matrix [J].

Flemming, Hans-Curt ;

Wingender, Jost .

NATURE REVIEWS MICROBIOLOGY, 2010, 8 (09) :623-633

[30] Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus [J].

Fowler, Sarah A. ;

Stacy, Danielle M. ;

Blackwell, Helen E. .

ORGANIC LETTERS, 2008, 10 (12) :2329-2332

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