Analysis of the Application of MMP-9 Inhibitor in Skin Melanoma: Experimental Study

被引：5

作者：

Aksenenko, M. B. ^{[1
]}

Ruksha, T. G. ^{[1
]}

机构：

[1] Prof VF Voyno Yasenetsky Krasnoyarsk State Med Un, Course Clin Pathophysiol, Prof VV Ivanov Dept Pathol Physiol, Krasnoyarsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 154卷 / 05期

关键词：

matrix metalloproteinase-9; skin melanoma; neoangiogenesis; MATRIX METALLOPROTEINASES; PATTERNS;

D O I：

10.1007/s10517-013-2007-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA(+) tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma. Therefore, this enzyme can be considered as a potential therapeutic target.

引用

页码：594 / 596

页数：3

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