Role of TGFβ in the Anti-Estrogen Response/Resistance of Human Breast Cancer

被引：13

作者：

Benson, John R. ^{[1
,2
]}

Baum, M. ^{[1
,2
]}

Colletta, Anthony A. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Hartwell Lab, Sect Acad Surg, London SW3 6JJ, England

[2] Royal Marsden Hosp, London SW3 6JJ, England

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 1996年 / 1卷 / 04期

关键词：

Anti-estrogens; breast cancer; TGF beta; autocrine; paracrine;

D O I：

10.1007/BF02017394

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transforming growth factor beta (TGF beta) has potent inhibitory effects upon epithelial proliferation and malignant progression may be associated with breakdown of the autocrine and paracrine inhibitory loops in which TGF beta participates. The therapeutic effects of anti-estrogens may be partially attributable to boosting of local endogenous levels of TGF beta. This article reviews the evidence in support of TGF beta being a proximate effector in mediation of the anti-neoplastic effects of anti-estrogens. Both the conventional estrogen receptor (ER)(3) dependent and ER independent mechanisms of action are likely to be involved. Evidence for preferential stromal induction of TGF beta by anti-estrogens is emphasized, together with the therapeutic potential of this strategy for improving outcome in early breast cancer irrespective of ER status.

引用

页码：381 / 389

页数：9

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