The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development

被引：184

作者：

Farkas, Lilla M. ^{[1
]}

Huttner, Wieland B. ^{[1
]}

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2008.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The switch of neural stem and progenitor cells from proliferation to differentiation during development is a crucial determinant of brain size. This switch is intimately linked to the architecture of the two principal classes of neural stem and progenitor cells, the apical (neuroepithelial, radial glial) and basal (intermediate) progenitors, which in turn is crucial for their symmetric versus asymmetric divisions. Focusing on the developing rodent neocortex, we discuss here recent advances in understanding the cell biology of apical and basal progenitors, place key regulatory molecules into subcellular context, and highlight their roles in the control of proliferation versus differentiation.

引用

页码：707 / 715

页数：9

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