Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss

被引：37

作者：

Boyle, David ^{[1
]}

Al-Bairuty, Genan A. ^{[1
]}

Henry, Theodore B. ^{[1
,2
,3
]}

Handy, Richard D. ^{[1
]}

机构：

[1] Univ Plymouth, Sch Biomed & Biol Sci, Ecotoxicol Res & Innovat Ctr, Plymouth PL4 8AA, Devon, England

[2] Univ Tennessee, Ctr Environm Biotechnol, Knoxville, TN 37996 USA

[3] Univ Tennessee, Dept Forestry Wildlife & Fisheries, Knoxville, TN 37996 USA

来源：

ENVIRONMENTAL POLLUTION | 2013年 / 182卷

基金：

英国自然环境研究理事会;

关键词：

Nanoparticles; Titanium dioxide; Rainbow trout; Toxicity; Bioavailability; TITANIUM-DIOXIDE NANOPARTICLES; OXIDATIVE STRESS; FISH; ECOTOXICOLOGY; TISSUE;

D O I：

10.1016/j.envpol.2013.07.001

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：70 / 79

页数：10

共 36 条

[1]

TiO2 Nanoparticle Exposure and Illumination during Zebrafish Development: Mortality at Parts per Billion Concentrations [J].