Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants

被引：77

作者：

Markine-Goriaynoff, D ^{[1
]}

Coutelier, JP ^{[1
]}

机构：

[1] Univ Catholique Louvain, Christian Duve Inst Cellular Pathol, Unit Expt Med, B-1200 Brussels, Belgium

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1128/JVI.76.1.432-435.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Immunoglobulin GI (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.

引用

收藏

页码：432 / 435

页数：4

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