Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants

被引：77

作者：

Markine-Goriaynoff, D ^{[1
]}

Coutelier, JP ^{[1
]}

机构：

[1] Univ Catholique Louvain, Christian Duve Inst Cellular Pathol, Unit Expt Med, B-1200 Brussels, Belgium

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1128/JVI.76.1.432-435.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Immunoglobulin GI (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.

引用

页码：432 / 435

页数：4

共 30 条

[21] MURINE IGG SUBCLASS RESPONSES TO HERPES-SIMPLEX VIRUS TYPE-1 AND POLYPEPTIDES [J].

MCKENDALL, RR ;

WOO, W .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :847-857

[22] DIFFERENCE IN NEUTRALIZATION BETWEEN LACTATE DEHYDROGENASE-ELEVATING VIRUS ISOLATED FROM ACUTELY AND CHRONICALLY INFECTED MICE [J].

MONTEYNE, P ;

COUTELIER, JP .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :1173-1176

[23]

MURPHY WH, 1983, PROG BRAIN RES, V59, P291

[24] VIRUS-NEUTRALIZING ANTIBODIES OF IMMUNOGLOBULIN-G (IGG) BUT NOT OF IGM OR IGA ISOTYPES CAN CURE INFLUENZA-VIRUS PNEUMONIA IN SCID MICE [J].

PALLADINO, G ;

MOZDZANOWSKA, K ;

WASHKO, G ;

GERHARD, W .

JOURNAL OF VIROLOGY, 1995, 69 (04) :2075-2081

[25] MODE OF NEUTRALIZATION OF LACTATE DEHYDROGENASE-ELEVATING VIRUS BY POLYCLONAL AND MONOCLONAL-ANTIBODIES [J].

PLAGEMANN, PGW ;

HARTY, JT ;

EVEN, C .

ARCHIVES OF VIROLOGY, 1992, 123 (1-2) :89-100

[26] RILEY VIRUS NEUTRALIZING ACTIVITY IN PLASMA OF INFECTED MICE WITH PERSISTENT VIRAEMIA [J].

ROWSON, KEK ;

MAHY, BWJ ;

BENDINELLI, M .

VIROLOGY, 1966, 28 (04) :775-+

[27] THE FC PORTION OF ANTIBODY TO YELLOW-FEVER VIRUS-NS1 IS A DETERMINANT OF PROTECTION AGAINST YF ENCEPHALITIS IN MICE [J].

SCHLESINGER, JJ ;

FOLTZER, M ;

CHAPMAN, S .

VIROLOGY, 1993, 192 (01) :132-141

[28] MURINE IMMUNOGLOBULIN-G SUBCLASS RESPONSES FOLLOWING IMMUNIZATION WITH LIVE DENGUE VIRUS OR A RECOMBINANT DENGUE ENVELOPE PROTEIN [J].

SMUCNY, JJ ;

KELLY, EP ;

MACARTHY, PO ;

KING, AD .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (04) :432-437

[29] THE IDENTIFICATION OF MONOCLONAL CLASS SWITCH VARIANTS BY SIB SELECTION AND AN ELISA ASSAY [J].

SPIRA, G ;

BARGELLESI, A ;

TEILLAUD, JL ;

SCHARFF, MD .

JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 74 (02) :307-315

[30] ROLES OF IMMUNOGLOBULIN VALENCY AND THE HEAVY-CHAIN CONSTANT DOMAIN IN ANTIBODY-MEDIATED DOWN-REGULATION OF SINDBIS VIRUS-REPLICATION IN PERSISTENTLY INFECTED NEURONS [J].

UBOL, S ;

LEVINE, B ;

LEE, SH ;

GREENSPAN, NS ;

GRIFFIN, DE .

JOURNAL OF VIROLOGY, 1995, 69 (03) :1990-1993

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