Histone variants and histone modifications:: A structural perspective

被引：51

作者：

Ausió, J ^{[1
]}

Abbott, DW ^{[1
]}

Wang, XY ^{[1
]}

Moore, SC ^{[1
]}

机构：

[1] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2001年 / 79卷 / 06期

关键词：

histone variants; posttranslational modifications; chromatin;

D O I：

10.1139/bcb-79-6-693

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels: short-range "local" or long-range "global", with different functional implications. Recent work on this topic emphasizes an earlier notion that suggests that, in many instances, the functional response to histone variability is possibly the result of a synergistic structural effect.

引用

页码：693 / 708

页数：16

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