Estrogen as treatment of hemorrhagic cystitis in children and adolescents undergoing bone marrow transplantation

被引：35

作者：

Heath, JA ^{[1
]}

Mishra, S ^{[1
]}

Mitchell, S ^{[1
]}

Waters, KD ^{[1
]}

Tiedemann, K ^{[1
]}

机构：

[1] Royal Childrens Hosp, Childrens Canc Ctr, Melbourne, Vic 3052, Australia

来源：

BONE MARROW TRANSPLANTATION | 2006年 / 37卷 / 05期

关键词：

hemorrhagic cystitis; hematopoietic stem cell transplantation; estrogen; cyclophosphamide; children and adolescents;

D O I：

10.1038/sj.bmt.1705280

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT) can cause significant morbidity and mortality. Previous reports have suggested a role for estrogen in the control of HC in adult patients. Here, we describe the clinical courses of 10 children and adolescents treated with estrogen for HC following HSCT. Eight patients (80%) experienced a significant improvement in their hematuria following the commencement of therapy, with six (60%) undergoing resolution of macroscopic hematuria, without any recurrences. The treatment was well tolerated by the majority of patients, with only one patient needing to interrupt treatment ( hepatotoxicity). We conclude that estrogen is well tolerated and often effective, and should be considered as an adjunctive treatment option in children and adolescents with HC following HSCT.

引用

页码：523 / 526

页数：4