Identification of a key recombinant narrows the CADASIL gene region to 8 cM and argues against allelism of CADASIL and familial hemiplegic migraine

被引：26

作者：

Dichgans, M

Mayer, M

MullerMyhsok, B

Straube, A

Gasser, T

机构：

[1] UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL,D-81377 MUNICH,GERMANY

[2] UNIV MUNICH,DEPT PEDIAT GEN,D-81377 MUNICH,GERMANY

[3] BERNHARD NOCHT INST TROP MED,D-20359 HAMBURG,GERMANY

来源：

GENOMICS | 1996年 / 32卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0094

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a nonarteriosclerotic, nonamyloid angiopathy characterized by recurrent subcortical ischemic strokes starting in midadulthood and frequently leading to pseudobulbar palsy and dementia. The disease locus has recently been mapped to chromosome 19q12. We have identified a chromosomal crossover in a clinically affected family member, which refines the localization of the CADASIL disease locus. Multipoint linkage analysis established the best estimate for the gene locus within an 8-cM interval bracketed by D195226 and D19S222. This estimate strongly argues against allelism of CADASIL and familial hemiplegic migraine. (C) 1996 Academic Press, Inc.

引用

页码：151 / 154

页数：4