The interplay between the Bcl-2 family and death receptor-mediated apoptosis

被引：167

作者：

Sprick, MR ^{[1
]}

Walczak, H ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, Dept Apoptosis Regulat, Tumor Immunol Program, D-69120 Heidelberg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1644卷 / 2-3期

关键词：

apoptosis; Bcl-2; family; death receptor;

D O I：

10.1016/j.bbamcr.2003.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two principal pathways for apoptosis initiation exist. One pathway, which is also termed the 'extrinsic' pathway, is mediated by death receptors, a subgroup of the TNF receptor superfamily. The second pathway, which is also referred to as the 'intrinsic' pathway, is controlled by members of the Bcl-2 family. A long-standing discussion revolves around the question of how these two pathways influence each other in regulating the decision about life or death of a cell. Here, we review our current knowledge about the interactions between these two pathways and discuss current models which could help to resolve previous apparently contradictory results. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：125 / 132

页数：8

共 99 条

[1]

Ahmad M, 1998, CANCER RES, V58, P5201

[2] Apaf-1/cytochrome capoptosome: an essential initiator of caspase activation or just a sideshow? [J].