Scope and limitations of the alkylidene carbene 1,5-CH insertion reactions of α-amino acid-derived substrates

被引：8

作者：

Mapitse, R ^{[1
]}

Hayes, CJ ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(02)00585-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of alpha-amino acid-derived cyclisation precursors were synthesised from suitably protected alpha-amino esters, via a Dibal-H/Wittig/catalytic hydrogenation strategy and each of these was subjected to alkylidene carbene-forming conditions (lithio(trimethylsilyl)diazomethane, THF). The cyclisations proceeded in poor to good yield, with the best cyclisations occurring to produce spirocyclic products. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：3541 / 3542

页数：2

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