Equinatoxins, pore-forming proteins from the sea anemone Actinia equina, belong to a multigene family

被引：64

作者：

Anderluh, G

Krizaj, I

Strukelj, B

Gubensek, F

Macek, P

Pungercar, J

机构：

[1] Univ Ljubljana, Biotech Fac, Dept Biol, Ljubljana 1000, Slovenia

[2] Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana 1000, Slovenia

来源：

TOXICON | 1999年 / 37卷 / 10期

关键词：

D O I：

10.1016/S0041-0101(99)00082-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The multigene family of equinatoxins, pore-forming proteins from sea anemone Actinia equina, has been studied at the protein and gene levels. We report the cDNA sequence of a new, sphingomyelin inhibited equinatoxin, EqtIV. The N-terminal sequences of natural Eqt I and III were also determined, confirming two isoforms of EqtI, differing at position 13, The number of Eqt genes determined by Southern blot hybridization was found to be more than five, indicating that Eqts belong to a multigene family. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1391 / 1401

页数：11