Glycoconjugates of gadolinium complexes for MRI applications

被引:79
作者
Fulton, DA
Elemento, EM
Aime, S
Chaabane, L
Botta, M
Parker, D
机构
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
[2] Univ Turin, Dipartimento Chim IFM, I-10125 Turin, Italy
[3] CNRS, Lab RMN, UMR 5012, F-69622 Villeurbanne, France
[4] Univ Piemonte Orientale, Dipartimento Sci Ambiente Vita, I-15100 Alessandria, Italy
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1039/b517997a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.
引用
收藏
页码:1064 / 1066
页数:3
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