Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates

被引：47

作者：

Fulton, DA

O'Halloran, M

Parker, D

Senanayake, K

Botta, M

Aime, S

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Univ Piemonte Orientale Amedro Avogadro, Dipmartimento Sci Ambiente Vita, I-15100 Alessandria, Italy

[3] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b413536a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.

引用

页码：474 / 476

页数：3

共 17 条

[1] Lanthanide(III) chelates for NMR biomedical applications [J].

Aime, S ;

Botta, M ;

Fasano, M ;

Terreno, E .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (01) :19-29

[2]

Aime Silvio, 2003, Met Ions Biol Syst, V40, P643

[3]

[Anonymous], 2001, ACOUSTIC CHARACTERIZ

[4] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

[5] The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates [J].

Caravan, P ;

Cloutier, NJ ;

Greenfield, MT ;

McDermid, SA ;

Dunham, SU ;

Bulte, JWM ;

Amedio, JC ;

Looby, RJ ;

Supkowski, RM ;

Horrocks, WD ;

McMurry, TJ ;

Lauffer, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (12) :3152-3162

[6] Optimization of the relaxivity of MRI contrast agents:: Effect of poly(ethylene glycol) chains on the water-exchange rates of GdIII complexes [J].

Doble, DMJ ;

Botta, M ;

Wang, J ;

Aime, S ;

Barge, A ;

Raymond, KN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (43) :10758-10759

[7] Synthesis and surface functionalization of aliphatic polyether dendrons [J].

Grayson, SM ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (42) :10335-10344

[8] Convergent synthesis and 'surface' functionalization of a dendritic analog of poly(ethylene glycol) [J].

Grayson, SM ;

Jayaraman, M ;

Fréchet, JMJ .

CHEMICAL COMMUNICATIONS, 1999, (14) :1329-1330

[9] UNIMOLECULAR MICELLES AND GLOBULAR AMPHIPHILES - DENDRITIC MACROMOLECULES AS NOVEL RECYCLABLE SOLUBILIZATION AGENTS [J].

HAWKER, CJ ;

WOOLEY, KL ;

FRECHET, JMJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (12) :1287-1297

[10] Poly(amidoamine) hyperbranched systems: synthesis, structure and characterization [J].

Hobson, LJ ;

Feast, WJ .

POLYMER, 1999, 40 (05) :1279-1297

← 1 2 →