The role of α-tocopherol in preventing disease: from epidemiology to molecular events

被引：84

作者：

Azzi, A. ^{[1
]}

Gysin, R. ^{[1
]}

Kempna, P. ^{[1
]}

Ricciarelli, R. ^{[2
]}

Villacorta, L. ^{[1
]}

Visarius, T. ^{[1
]}

Zingg, J. -M. ^{[1
]}

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland

[2] Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy

来源：

MOLECULAR ASPECTS OF MEDICINE | 2003年 / 24卷 / 06期

关键词：

Vitamin E; Tocopherols; Gene expression; Non-antioxidant; Cell signaling; Protein kinase C;

D O I：

10.1016/S0098-2997(03)00028-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of vitamin E has been attributed to its capacity to protect the organism against the attack of free radicals by acting as a lipid based radical chain breaking molecule. More recently, alternative non-antioxidant functions of vitamin E have been proposed and in particular that of a "gene regulator". Effects of vitamin E have been observed at the level of mRNA or protein and could be consequent to regulation of gene transcription, mRNA stability, protein translation, protein stability and post-translational events. Given the high priority functions assigned to vitamin E, it can be speculated that it would be inefficient to consume it as a radical scavenger. Rather, it would be important to protect vitamin E through a network of cellular antioxidant defences, similarly to what occurs with proteins, nucleic acids and lipids. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：325 / 336

页数：12

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