Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions

被引：94

作者：

Fu, Xiaobing ^{[1
]}

Li, Haihong ^{[2
]}

机构：

[1] Gen Hosp PLA, Postgrad Med Coll, Ctr Trauma, Inst Basic Med Sci, Beijing 100853, Peoples R China

[2] Shantou Univ, Coll Med, Shantou 515063, Guangdong, Peoples R China

来源：

CELL AND TISSUE RESEARCH | 2009年 / 335卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Mesenchymal stem cells; Skin; Injury; Repair; Regeneration; FIBROBLAST-GROWTH-FACTOR; BONE; THERAPY; TISSUE; DIFFERENTIATION; MICE; TRANSDIFFERENTIATION; PARTICIPATION; MEDICINE; SURGERY;

D O I：

10.1007/s00441-008-0724-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adult mesenchymal stem cells (MSCs) have the capacity for self-renewal and for differentiating into a variety of cells and tissues. They may leave their niche to migrate to remote tissues and play a critical role in wound repair and tissue regeneration. Because of their multipotency, easy isolation and culture, highly expansive potential, and immunosuppression properties, these cells may be an attractive therapeutic tool for regenerative medicine and tissue engineering. Several studies have indicated a contribution of MSCs to reconstituting skin in cutaneous wounds, but problems still need resolution before MSCs can be widely used clinically. This review focuses mainly on the benefits of MSCs in skin wound healing and tissue regeneration and on the questions that remain to be answered before MSCs can be used in clinical practice.

引用

页码：317 / 321

页数：5

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