Synthesis of C-5′-nor-dideoxycarbanucleosides structurally related to neplanocin C

被引：13

作者：

Comin, MJ

Pujol, CA

Damonte, EB

Rodriguez, JB

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Virol Lab, RA-1428 Buenos Aires, DF, Argentina

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1999年 / 18卷 / 10期

关键词：

D O I：

10.1080/07328319908044877

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.

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收藏

页码：2219 / 2231

页数：13

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