Monitoring of microenvironmental changes in the major and minor grooves of DNA by dan-modified oligonucleotides

被引：43

作者：

Kimura, T ^{[1
]}

Kawai, K ^{[1
]}

Majima, T ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Osaka 5670047, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 26期

关键词：

D O I：

10.1021/ol052473m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis of new environmentally sensitive fluorescence probes to elucidate DNA structures. DNA oligonucleotides containing fluorophore dan (6-(dimethylamino)-2-acylnaphthalene)-modified dC or dG were able to monitor the microenvironmental changes in both the major and minor grooves of DNA with a B- to A-DNA conformational transition and RNA hybridization.

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页码：5829 / 5832

页数：4

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