A high-yield synthesis of deoxy-2-fluoroinosine and its incorporation into oligonucleotides.

被引：27

作者：

Adib, A ^{[1
]}

Potier, PF ^{[1
]}

Doronina, S ^{[1
]}

Huc, I ^{[1
]}

Behr, JP ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR STRASBOURG 1,FAC PHARMACEUT STRASBOURG,CNRS,LAB CHIM GENET,F-67401 ILLKIRCH GRAFFENS,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(97)00540-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved synthesis of the deoxy-2-fluoroinosine nucleoside is described, that makes use of mild fluorination (polyvinylpyridinium polyhydrogenfluoride) and O-silyl deprotection (triethylamine trihydrofluoride) reactions. The derived 5'-dimethoxytrityl-2-fluoroinosine-3'-phosphoramidite was incorporated into 10-, 15- and 20- mer oligonucleotides containing up to 7 non-natural bases. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：2989 / 2992

页数：4

共 24 条

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