Effects of medium-chain fatty acids and their acylglycerols on the transport of penicillin V across Caco-2 cell monolayers

被引：24

作者：

Shima, M ^{[1
]}

Yohdoh, K ^{[1
]}

Yamaguchi, M ^{[1
]}

Kimura, Y ^{[1
]}

Adachi, S ^{[1
]}

Matsuno, R ^{[1
]}

机构：

[1] KYOTO UNIV, FAC AGR, DEPT FOOD SCI & TECHNOL, SAKYO KU, KYOTO 60601, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 07期

关键词：

Caco-2; transepithelial transport; medium-chain fatty acids and acylglycerols; surface activity; physico-chemical property;

D O I：

10.1271/bbb.61.1150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transport-enhancing effects of medium-chain fatty acids (caproic, caprylic, and capric acids) and their acylglycerols (mono-, di-, triacylglycerols) were investigated by using Caco-2 cell monolayers as a model of the human intestinal epithelium. Penicillin V was used as a model for a hydrophilic bioactive compound. Among the fatty acids and acylglycerols tested, 1,2-dicaproin, monocaprin, monocaprylin, and capric acid sodium salt effectively enhanced the transport rate, whereas other substances enhanced the rate only slightly or not at all. With each of these four substance, the rate of enhancement was proportional to the concentration at low concentrations, but leveled off at high concentrations. The transport-enhancing effects were well correlated with the reduction in surface tension and with a physico-chemical parameter, denoted by the surface energy-lowering coefficient, characterizing the surface activity of a substance.

引用

页码：1150 / 1155

页数：6

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