共 156 条
Recent insights into the pathogenesis and therapeutics of pulmonary hypertension
被引:25
作者:

Strange, JW
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机构:
Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England

Wharton, J
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Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England

Phillips, PG
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Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England

Wilkins, MR
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h-index: 0
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Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England
机构:
[1] Hammersmith Hosp, Imperial Coll, Clin Pharmacol Sect, London W12 0NN, England
关键词:
BMP type II receptor;
genetic predisposition;
hypoxia;
pulmonary hypertension;
therapeutics;
transforming growth;
factor beta receptor;
D O I:
10.1042/CS20010212
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
The normal adult pulmonary circulation is a low-pressure, high-capacity circuit. Pulmonary vascular resistance is regulated by alveolar oxygen tension, potassium channels and a variety of locally produced and circulating vasoactive factors. Perturbations of these systems may contribute to the pathogenesis of pulmonary hypertension. Recently, mutations in BMPR2 and ALK-1, genes that encode members of the transforming growth factor-beta (TGF-beta) receptor superfamily, have been found in patients with primary pulmonary hypertension. These observations provide a novel insight into the pathogenesis of primary pulmonary hypertension, and emphasize the importance of the integrity of the TGF-beta receptor family in the maintenance of normal pulmonary vascular structure and function. This review discusses the latest developments in the field of pulmonary vascular biology and the prospects for improving the treatment of pulmonary hypertension.
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页码:253 / 268
页数:16
相关论文
共 156 条
[91]
Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32
[J].
Morse, JH
;
Jones, AC
;
Barst, RJ
;
Hodge, SE
;
Wilhelmsen, KC
;
Nygaard, TG
.
CIRCULATION,
1997, 95 (12)
:2603-2606

Morse, JH
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

Jones, AC
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

Barst, RJ
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

Hodge, SE
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

Wilhelmsen, KC
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

Nygaard, TG
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032
[92]
MICROPUNCTURE MEASUREMENT OF LUNG MICROVASCULAR PRESSURE PROFILE DURING HYPOXIA IN CATS
[J].
NAGASAKA, Y
;
BHATTACHARYA, J
;
NANJO, S
;
GROPPER, MA
;
STAUB, NC
.
CIRCULATION RESEARCH,
1984, 54 (01)
:90-95

NAGASAKA, Y
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

BHATTACHARYA, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

NANJO, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

GROPPER, MA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

STAUB, NC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143
[93]
Haemodynamic and hormonal effects of adrenomedullin in patients with pulmonary hypertension
[J].
Nagaya, N
;
Nishikimi, T
;
Uematsu, M
;
Satoh, T
;
Oya, H
;
Kyotani, S
;
Sakamati, F
;
Ueno, K
;
Nakanishi, N
;
Miyatake, K
;
Kangawa, K
.
HEART,
2000, 84 (06)
:653-658

Nagaya, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Nishikimi, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Uematsu, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Satoh, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Oya, H
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Kyotani, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Sakamati, F
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Ueno, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Nakanishi, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Miyatake, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Kangawa, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan
[94]
Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats
[J].
Nagaya, N
;
Yokoyama, C
;
Kyotani, S
;
Shimonishi, M
;
Morishita, R
;
Uematsu, M
;
Nishikimi, T
;
Nakanishi, N
;
Ogihara, T
;
Yamagishi, M
;
Miyatake, K
;
Kaneda, Y
;
Tanabe, T
.
CIRCULATION,
2000, 102 (16)
:2005-2010

Nagaya, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Yokoyama, C
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Kyotani, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Shimonishi, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Morishita, R
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Uematsu, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Nishikimi, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Nakanishi, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Ogihara, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Yamagishi, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Miyatake, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Kaneda, Y
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan

Tanabe, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 5658565, Japan
[95]
Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension
[J].
Nagaya, N
;
Uematsu, M
;
Okano, Y
;
Satoh, T
;
Kyotani, S
;
Sakamaki, F
;
Nakanishi, N
;
Miyatake, K
;
Kunieda, T
.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,
1999, 34 (04)
:1188-1192

Nagaya, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Uematsu, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Okano, Y
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Satoh, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Kyotani, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Sakamaki, F
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Nakanishi, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Miyatake, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan

Kunieda, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Cardiovasc Ctr, Dept Med, Div Cardiol, Suita, Osaka 565, Japan
[96]
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
[J].
Nakaoka, T
;
Gonda, K
;
Ogita, T
;
Otawara-Hamamoto, Y
;
Okabe, F
;
Kira, Y
;
Harii, K
;
Miyazono, K
;
Takuwa, Y
;
Fujita, T
.
JOURNAL OF CLINICAL INVESTIGATION,
1997, 100 (11)
:2824-2832

Nakaoka, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Gonda, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Ogita, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Otawara-Hamamoto, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Okabe, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Kira, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Harii, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Miyazono, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Takuwa, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan

Fujita, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Sch Med, Dept Internal Med 4, Bunkyo Ku, Tokyo 112, Japan
[97]
Endothelin-1 inhibits endothelin-converting enzyme-1 expression in cultured rat pulmonary endothelial cells
[J].
Naomi, S
;
Iwaoka, T
;
Disashi, T
;
Inoue, J
;
Kanesaka, Y
;
Tokunaga, H
;
Tomita, K
.
CIRCULATION,
1998, 97 (03)
:234-236

Naomi, S
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Iwaoka, T
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Disashi, T
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Inoue, J
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Kanesaka, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Tokunaga, H
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan

Tomita, K
论文数: 0 引用数: 0
h-index: 0
机构:
Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 3, Kumamoto 860, Japan
[98]
Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
[J].
Nichols, WC
;
Koller, DL
;
Slovis, B
;
Foroud, T
;
Terry, VH
;
Arnold, ND
;
Siemieniak, DR
;
Wheeler, L
;
Phillips, JA
;
Newman, JH
;
Conneally, PM
;
Ginsburg, D
;
Loyd, JE
.
NATURE GENETICS,
1997, 15 (03)
:277-280

Nichols, WC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Koller, DL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Slovis, B
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Foroud, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Terry, VH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Arnold, ND
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Siemieniak, DR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Wheeler, L
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Phillips, JA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Newman, JH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Conneally, PM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Ginsburg, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA

Loyd, JE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA
[99]
ARTERIAL OXYGEN-SATURATION IN TIBETAN AND HAN INFANTS BORN IN LHASA, TIBET
[J].
NIERMEYER, S
;
YANG, P
;
SHANMINA
;
DROLKAR
;
ZHUANG, JG
;
MOORE, LG
.
NEW ENGLAND JOURNAL OF MEDICINE,
1995, 333 (19)
:1248-1252

NIERMEYER, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO

YANG, P
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO

SHANMINA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO

DROLKAR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO

ZHUANG, JG
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO

MOORE, LG
论文数: 0 引用数: 0
h-index: 0
机构: UNIV COLORADO,SCH MED,DEPT PEDIAT,NEONATOL SECT,DENVER,CO
[100]
Inhaled iloprost to treat severe pulmonary hypertension -: An uncontrolled trial
[J].
Olschewski, H
;
Ghofrani, HA
;
Schmehl, T
;
Winkler, J
;
Wilkens, H
;
Höper, MM
;
Behr, J
;
Kleber, FX
;
Seeger, W
.
ANNALS OF INTERNAL MEDICINE,
2000, 132 (06)
:435-+

Olschewski, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Ghofrani, HA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Schmehl, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Winkler, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Wilkens, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Höper, MM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Behr, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Kleber, FX
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany

Seeger, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Giessen, Dept Internal Med 2, D-35392 Giessen, Germany