Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment

被引：33

作者：

Demaria, Sandra ^{[1
,2
]}

Pilones, Karsten A. ^{[1
]}

Formenti, Silvia C. ^{[2
]}

Dustin, Michael L. ^{[1
,3
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10012 USA

[2] NYU, Sch Med, Dept Radiat Oncol, New York, NY USA

[3] NYU, Sch Med, Helen L & Martin S Kimmel Ctr Biol & Med, Program Mol Pathogenesis,Skirball Inst Biomol Med, New York, NY USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

abscopal effect; CTLA-4; ipilimumab; NKG2D; RAE-1; radiotherapy; synergy; tumor rejection; BREAST-CANCER; RADIOTHERAPY; INHIBITION; THERAPY; CTLA-4;

D O I：

10.4161/onci.23127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors must be engaged for the elicitation of CD8(+) T-cell antitumor responses has important clinical implications.

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