Age-related prefrontal alterations during auditory memory

被引:37
作者
Chao, LL
Knight, RT
机构
[1] UNIV CALIF DAVIS, DEPT NEUROL, DAVIS, CA 95616 USA
[2] UNIV CALIF DAVIS, CTR NEUROSCI, DAVIS, CA 95616 USA
[3] VET ADM MED CTR, DEPT NEUROL 127, MARTINEZ, CA 94553 USA
关键词
prefrontal cortex; auditory memory; P300; N400;
D O I
10.1016/S0197-4580(96)00161-3
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Event-related potentials were recorded from young and elderly subjects while they performed a modified auditory Sternberg memory task. Aging was associated with a decrease in frontal activation, suggesting that prefrontal alterations may be central to age-related impairments in auditory working memory. Young subjects showed significant serial position effects electrophysiologically, while elderly subjects showed no recency effects for P3 latency and no serial position effects for N4 and SFN amplitude. This finding, in combination with increased false alarm rates in the elderly, suggest that the two group of subjects employed different cortico-limbic circuits to perform the task. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码:87 / 95
页数:9
相关论文
共 98 条
  • [1] ALBERT MS, 1980, NEW DIRECTIONS MEMOR
  • [2] CONVERGENCE OF PREFRONTAL AND ACOUSTIC INPUTS UPON NEURONS IN SUPERIOR TEMPORAL GYRUS OF AWAKE SQUIRREL-MONKEY
    ALEXANDER, GE
    NEWMAN, JD
    SYMMES, D
    [J]. BRAIN RESEARCH, 1976, 116 (02) : 334 - 338
  • [3] [Anonymous], J PSYCHOPHYSIOLOGY
  • [4] ANALYSIS OF ALPHA-2 ADRENERGIC AGONIST EFFECTS ON THE DELAYED NONMATCH-TO-SAMPLE PERFORMANCE OF AGED RHESUS-MONKEYS
    ARNSTEN, AFT
    GOLDMANRAKIC, PS
    [J]. NEUROBIOLOGY OF AGING, 1990, 11 (06) : 583 - 590
  • [5] ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES
    ARNSTEN, AFT
    GOLDMANRAKIC, PS
    [J]. SCIENCE, 1985, 230 (4731) : 1273 - 1276
  • [6] AGED MONKEYS EXHIBIT BEHAVIORAL DEFICITS INDICATIVE OF WIDESPREAD CEREBRAL-DYSFUNCTION
    BACHEVALIER, J
    LANDIS, LS
    WALKER, LC
    BRICKSON, M
    MISHKIN, M
    PRICE, DL
    CORK, LC
    [J]. NEUROBIOLOGY OF AGING, 1991, 12 (02) : 99 - 111
  • [7] REACTION-TIME AND SHORT-TERM-MEMORY - IMPLICATIONS OF REPETITION EFFECTS FOR HIGH-SPEED EXHAUSTIVE SCAN HYPOTHESIS
    BADDELEY, AD
    ECOB, JR
    [J]. QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1973, 25 (MAY): : 229 - 240
  • [8] Birbaumer N, 1984, SELF REGULATION BRAI, P9
  • [9] EXPONENTIAL ELECTRO-PHYSIOLOGICAL AGING - P3-LATENCY
    BROWN, WS
    MARSH, JT
    LARUE, A
    [J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1983, 55 (03): : 277 - 285
  • [10] COGNITIVE DEFICIT CAUSED BY REGIONAL DEPLETION OF DOPAMINE IN PREFRONTAL CORTEX OF RHESUS-MONKEY
    BROZOSKI, TJ
    BROWN, RM
    ROSVOLD, HE
    GOLDMAN, PS
    [J]. SCIENCE, 1979, 205 (4409) : 929 - 932