From haematopoietic stem cells to complex differentiation landscapes

被引：617

作者：

Laurenti, Elisa ^{[1
,2
]}

Goettgens, Berthold ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge, England

[2] Univ Cambridge, Wellcome & MRC Cambridge Stem Cell Inst, Cambridge, England

来源：

NATURE | 2018年 / 553卷 / 7689期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

DNA METHYLATION DYNAMICS; GENE-EXPRESSION ANALYSIS; HUMAN CORD BLOOD; IN-VIVO; SELF-RENEWAL; LINEAGE COMMITMENT; PROGENITOR CELLS; BONE-MARROW; MULTIPOTENT PROGENITORS; MEGAKARYOCYTE PROGENITORS;

D O I：

10.1038/nature25022

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and nonmalignant haematopoietic diseases.

引用

收藏

页码：418 / 426

页数：9

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