Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

被引：152

作者：

Beerman, Isabel ^{[1
,2
,3
]}

Rossi, Derrick J. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Div Hematol Oncol, Program Cellular & Mol Med, Boston, MA 02116 USA

来源：

CELL STEM CELL | 2015年 / 16卷 / 06期

关键词：

REGULATES HEMATOPOIETIC STEM; DNA METHYLATION CHANGES; ADULT HIPPOCAMPAL NEUROGENESIS; REPRESSIVE COMPLEX 2; LONG-TERM CULTURE; GENOME-WIDE MAPS; SELF-RENEWAL; MYELODYSPLASTIC SYNDROME; HISTONE DEACETYLASE; PROGENITOR CELLS;

D O I：

10.1016/j.stem.2015.05.009

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell function, and emerging evidence indicates that epigenetic dysregulation contributes to the altered potential of stem cells during aging. Unlike terminally differentiated cells, the impact of epigenetic dysregulation in stem cells is propagated beyond self; alterations can be heritably transmitted to differentiated progeny, in addition to being perpetuated and amplified within the stem cell pool through self-renewal divisions. This Review focuses on recent studies examining epigenetic regulation of tissue-specific stem cells in homeostasis, aging, and aging-related disease.

引用

收藏

页码：613 / 625

页数：13

相关论文

共 159 条

[1]

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression [J].

Abdel-Wahab, Omar ;

Adli, Mazhar ;

LaFave, Lindsay M. ;

Gao, Jie ;

Hricik, Todd ;

Shih, Alan H. ;

Pandey, Suveg ;

Patel, Jay P. ;

Chung, Young Rock ;

Koche, Richard ;

Perna, Fabiana ;

Zhao, Xinyang ;

Taylor, Jordan E. ;

Park, Christopher Y. ;

Carroll, Martin ;

Melnick, Ari ;

Nimer, Stephen D. ;

Jaffe, Jacob D. ;

Aifantis, Iannis ;

Bernstein, Bradley E. ;

Levine, Ross L. .

CANCER CELL, 2012, 22 (02) :180-193

[2]

[Anonymous], 2011, ANGEW CHEM INT EDIT

[3]

Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis [J].

Attema, Joanne L. ;

Papathanasiou, Peter ;

Forsberg, E. Camilla ;

Xu, Jian ;

Smale, Stephen T. ;

Weissman, Irving L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (30) :12371-12376

[4]

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation [J].

Barreto, Guillermo ;

Schaefer, Andrea ;

Marhold, Joachim ;

Stach, Dirk ;

Swaminathan, Suresh K. ;

Handa, Vikas ;

Doederlein, Gabi ;

Maltry, Nicole ;

Wu, Wei ;

Lyko, Frank ;

Niehrs, Christof .

NATURE, 2007, 445 (7128) :671-675

[5]

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation [J].

Bartke, Till ;

Vermeulen, Michiel ;

Xhemalce, Blerta ;

Robson, Samuel C. ;

Mann, Matthias ;

Kouzarides, Tony .

CELL, 2010, 143 (03) :470-484

[6]

In vivo genome editing using a high-efficiency TALEN system [J].

Bedell, Victoria M. ;

Wang, Ying ;

Campbell, Jarryd M. ;

Poshusta, Tanya L. ;

Starker, Colby G. ;

Krug, Randall G., II ;

Tan, Wenfang ;

Penheiter, Sumedha G. ;

Ma, Alvin C. ;

Leung, Anskar Y. H. ;

Fahrenkrug, Scott C. ;

Carlson, Daniel F. ;

Voytas, Daniel F. ;

Clark, Karl J. ;

Essner, Jeffrey J. ;

Ekker, Stephen C. .

NATURE, 2012, 491 (7422) :114-U133

[7]

Epigenetic regulation of hematopoietic stem cell aging [J].

Beerman, Isabel ;

Rossi, Derrick J. .

EXPERIMENTAL CELL RESEARCH, 2014, 329 (02) :192-199

[8]

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle [J].

Beerman, Isabel ;

Seita, Jun ;

Inlay, Matthew A. ;

Weissman, Irving L. ;

Rossi, Derrick J. .

CELL STEM CELL, 2014, 15 (01) :37-50

[9]

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging [J].

Beerman, Isabel ;

Bock, Christoph ;

Garrison, Brian S. ;

Smith, Zachary D. ;

Gu, Hongcang ;

Meissner, Alexander ;

Rossi, Derrick J. .

CELL STEM CELL, 2013, 12 (04) :413-425

[10]

Impact of genomic damage and ageing on stem cell function [J].

Behrens, Axel ;

van Deursen, Jan M. ;

Rudolph, K. Lenhard ;

Schumacher, Bjoern .

NATURE CELL BIOLOGY, 2014, 16 (03) :201-207

← 1 2 3 4 5 6 7 8 9 10 →