Nitrogen-15 NMR spectroscopy of N-metallated nucleic acids:: insights into 15N NMR parameters and N-metal bonds

被引：41

作者：

Tanaka, Yoshiyuki ^{[1
]}

Ono, Akira ^{[2
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Mol Transformat, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Kanagawa Univ, Fac Engn, Dept Mat & Life Chem, Kanagawa Ku, Yokohama, Kanagawa 2218686, Japan

来源：

DALTON TRANSACTIONS | 2008年 / 37期

关键词：

D O I：

10.1039/b803510p

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

It was recently demonstrated spectroscopically that RNA/DNA nucleobases can bind to metal cations in aqueous solution through coordination bonds and covalent bonds. Nitrogen-15 (N-15) NMR spectroscopy was employed and shown to be a powerful tool for determining the mode of metal ion binding to nitrogen atoms in RNA/DNA molecules. This review describes N-15 NMR spectroscopic characteristics in accordance with the mode of metal ion binding to nitrogen atoms. The general rules for N-15 chemical shift changes, which are applicable to the determination of the metal ion binding mode of N-metallated compounds, are also described.

引用

页码：4965 / 4974

页数：10

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