Next-generation sequencing in the clinic: are we ready?

被引：94

作者：

Biesecker, Leslie G. ^{[1
]}

Burke, Wylie ^{[2
]}

Kohane, Isaac ^{[3
]}

Plon, Sharon E. ^{[4
,5
,6
]}

Zimmern, Ron ^{[7
]}

机构：

[1] NHGRI, Genet Dis Res Branch, Bethesda, MD 20892 USA

[2] Univ Washington, Dept Bioeth & Humanities, Seattle, WA 98195 USA

[3] Boston Childrens Hosp, Boston, MA 02115 USA

[4] Texas Childrens Hosp, Baylor Coll Med, Baylor Canc Genet Clin, Human Genome Sequencing Ctr,Dept Pediat, Houston, TX 77030 USA

[5] Texas Childrens Hosp, Baylor Coll Med, Baylor Canc Genet Clin, Human Genome Sequencing Ctr,Dept Hematol Oncol, Houston, TX 77030 USA

[6] Texas Childrens Hosp, Baylor Coll Med, Baylor Canc Genet Clin, Human Genome Sequencing Ctr,Dept Mol & Human Gene, Houston, TX 77030 USA

[7] PHG Fdn, Cambridge CB1 8RN, England

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 11期

关键词：

CANCER-SUSCEPTIBILITY; GENOMIC MEDICINE; NATIONAL SOCIETY; RISK; RECOMMENDATIONS; RECORDS; CARE;

D O I：

10.1038/nrg3357

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We are entering an era in which the cost of clinical whole-genome and targeted sequencing tests is no longer prohibitive to their application. However, currently the infrastructure is not in place to support both the patient and the physicians that encounter the resultant data. Here, we ask five experts to give their opinions on whether clinical data should be treated differently from other medical data, given the potential use of these tests, and on the areas that must be developed to improve patient outcome.

引用

页码：818 / 824

页数：7

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