Solid-phase synthesis of α-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP inhibitors

被引：34

作者：

Chollet, AM

Le Diguarher, T

Kucharczyk, N

Loynel, A

Bertrand, M

Tucker, G

Guilbaud, N

Burbridge, M

Pastoureau, P

Fradin, A

Sabatini, M

Fauchère, JL

Casara, P

机构：

[1] Inst Rech Servier, F-78290 Croissy Sur Seine, France

[2] Inst Rech Servier, F-92150 Suresnes, France

[3] Technol Servier, F-45007 Orleans, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0968-0896(01)00311-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by alpha and aryl substitutions on 3-arylthio-w-hydroxy-propionamides starting from itaconic acid. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：531 / 544

页数：14

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