Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites

被引：84

作者：

Kakeya, H

Onose, R

Koshino, H

Yoshida, A

Kobayashi, K

Kageyama, S

Osada, H

机构：

[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan

[2] RIKEN, Characterizat Ctr, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 14期

关键词：

D O I：

10.1021/ja0127279

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 μg/mL). Copyright © 2002 American Chemical Society.

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页码：3496 / 3497

页数：2

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