IL-17 and the Th17 lineage in systemic lupus erythematosus

被引:135
作者
Garrett-Sinha, Lee Ann [1 ]
John, Shinu
Gaffen, Sarah L. [2 ,3 ,4 ]
机构
[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Biochem, Ctr Excellence Bioinformat B3 306, Buffalo, NY 14203 USA
[2] SUNY Buffalo, Sch Dent Med, Dept Oral Biol, Buffalo, NY 14203 USA
[3] SUNY Buffalo, Sch Med & Biomed Sci, Dept Microbiol & Immunol, Buffalo, NY 14203 USA
[4] Univ Pittsburgh, Div Clin Immunol & Rheumatol, Pittsburgh, PA USA
关键词
chemokines; interleukin-17; lupus; mouse model; Th17;
D O I
10.1097/BOR.0b013e328304b6b5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Systemic lupus erythematosus etiology includes both genetic and environmental factors. Evidence suggests that many genetic loci in humans and mouse models contribute to the occurrence and clinical presentation of lupus. This large array of different genes affects many aspects of immune cell function, including the activation and functional differentiation of B cells, T cells, dendritic cells and other immune cells. In particular, the T-cell components that contribute to systemic lupus erythematosus pathogenesis are incompletely defined. Recent findings A major paradigm shift in understanding how CD4(+) T cells contribute to autoimmunity recently occurred with the discovery of a new T-cell population that produces the cytokine IL-17 (IL-17A), termed 'Th17'. Although Th17 cells contribute to autoimmune disease in rheumatoid arthritis and Crohn's disease, their role in systemic lupus erythematosus is far less clear. Summary In this review, we focus on an emerging role for the cytokine IL-17 and the cells that produce it in contributing to lupus in particular based on recent findings in animal models.
引用
收藏
页码:519 / 525
页数:7
相关论文
共 62 条
  • [1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
    Acosta-Rodriguez, Eva V.
    Napolitani, Giorgio
    Lanzavecchia, Antonio
    Sallusto, Federica
    [J]. NATURE IMMUNOLOGY, 2007, 8 (09) : 942 - 949
  • [2] Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    Aggarwal, S
    Ghilardi, N
    Xie, MH
    de Sauvage, FJ
    Gurney, AL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) : 1910 - 1914
  • [3] Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    Akimzhanov, Askar M.
    Yang, Xuexian O.
    Dong, Chen
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (09) : 5969 - 5972
  • [4] IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together
    Bettelli, E
    Kuchroo, VK
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) : 169 - 171
  • [5] A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    Chan, FKM
    Chun, HJ
    Zheng, LX
    Siegel, RM
    Bui, KL
    Lenardo, MJ
    [J]. SCIENCE, 2000, 288 (5475) : 2351 - 2354
  • [6] A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    Chang, Seon Hee
    Dong, Chen
    [J]. CELL RESEARCH, 2007, 17 (05) : 435 - 440
  • [7] Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
    Chang, Seon Hee
    Park, Heon
    Dong, Chen
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) : 35603 - 35607
  • [8] TGF-β, a 'double agent' in the immune pathology war
    Cua, DJ
    Kastelein, RA
    [J]. NATURE IMMUNOLOGY, 2006, 7 (06) : 557 - 559
  • [9] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Cua, DJ
    Sherlock, J
    Chen, Y
    Murphy, CA
    Joyce, B
    Seymour, B
    Lucian, L
    To, W
    Kwan, S
    Churakova, T
    Zurawski, S
    Wiekowski, M
    Lira, SA
    Gorman, D
    Kastelein, RA
    Sedgwick, JD
    [J]. NATURE, 2003, 421 (6924) : 744 - 748
  • [10] Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96
    Dai, Jie
    Liu, Bei
    Cua, Daniel J.
    Li, Zihai
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (03) : 706 - 715