Gonadal steroids in the treatment of mood disorders

被引:82
作者
Epperson, CN
Wisner, KL
Yamamoto, B
机构
[1] Yale Univ, Sch Med, Yale Behav Gynecol Program, Dept Psychiat,Connecticut Mental Hlth Ctr, New Haven, CT 06511 USA
[2] Case Western Reserve Univ, Sch Med, Mood Disorders Program, Dept Psychiat & Reprod Biol, Cleveland, OH USA
[3] Case Western Reserve Univ, Sch Med, Dept Psychiat & Neurosci, Cleveland, OH USA
来源
PSYCHOSOMATIC MEDICINE | 1999年 / 61卷 / 05期
关键词
gonadal steroids; depression; treatment; libido;
D O I
10.1097/00006842-199909000-00010
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Increased interest in the complex interplay between gonadal steroids and neurotransmitter systems involved in mood has led investigators to question the role of gonadal steroids in the treatment of affective disorders, especially in women. Objectives: The purpose of this article is to provide a rationale for using gonadal hormones in the treatment of depression in women. Methods: The literature is reviewed regarding 1) sex-specific phenomenologic and epidemiologic differences in the manifestation of psychiatric illness, 2) sex-specific differences in the therapeutic and adverse effects of psychotropic medications, 3) the complex interplay between gonadal steroids and neurotransmitter systems implicated in psychiatric disorders, and 4) the growing literature regarding the use of estrogen and progesterone in the treatment of mood disorders in women and androgens in the treatment of depression and sexual dysfunction in both men and women. Results: Findings from pharmacologic trials of estrogen and androgens are encouraging, albeit mixed, in the treatment of mood disorders and decreased libido in women, respectively. Controlled studies have failed to confirm early open-label reports of the effectiveness of progesterone in the treatment of premenstrual syndrome. Conclusions: Pending replication, estrogen may become an important pharmacologic agent in the treatment of postnatal and perimenopausal depression, whereas androgens have been shown to improve libido in postmenopausal women and hypogonadal men. Progesterone cannot be recommended as a treatment for premenstrual sydrome or postnatal depression.
引用
收藏
页码:676 / 697
页数:22
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