Conformational studies of the linear homooligomers of a glucosederived furanoid sugar amino acid

被引：19

作者：

Chakraborty, TK ^{[1
]}

Srinivasu, P ^{[1
]}

Madhavendra, SS ^{[1
]}

Kumar, SK ^{[1
]}

Kunwar, AC ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 18期

关键词：

sugar amino acids; oligomer; hydrogen bonding; conformation; NMR;

D O I：

10.1016/j.tetlet.2004.03.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conformational analysis of the linear tetramer of the glucose-derived furanoid sugar amino acid 1 by NMR and constrained molecular dynamics studies revealed that the fully protected tetramer 2a has a well-defined structure in CDCl3 with repeating P-turns, each involving a 10-membered ring structure with intramolecular hydrogen bonds between NHi --> C=Oi-2. Its deprotected versions 2b and 2c showed aggregation in organic solvents with structures similar to that of 2a. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3573 / 3577

页数：5

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