Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

被引：46

作者：

Zhang, Z

Zhao, YL

Batres, Y

Lin, MF

Ying, SY

机构：

[1] UNIV SO CALIF,SCH MED,DEPT CELL & NEUROBIOL,LOS ANGELES,CA 90033

[2] UNIV NEBRASKA,MED CTR,COLL MED,DEPT BIOCHEM MOL BIOL,OMAHA,NE 68198

[3] UNIV NEBRASKA,MED CTR,COLL MED,SECT UROL SURG,OMAHA,NE 68198

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 234卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.6649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activin A, a homodimer of the beta A subunit of inhibin, is a member of the TGF-beta family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells. (C) 1997 Academic Press.

引用

页码：362 / 365

页数：4

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