Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET

被引：131

作者：

Toyama, H ^{[1
]}

Ichise, M

Liow, JS

Vines, DC

Seneca, NM

Modell, KJ

Seidel, J

Green, MV

Innis, RB

机构：

[1] NIMH, Mol Imaging Branch, NIH, Bethesda, MD 20892 USA

[2] NIH, Warren Grant Magnuson Clin Ctr, Dept Nucl Med, Bethesda, MD 20892 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 02期

关键词：

small animal PET; mouse; F-18]FDG; anesthesia; brain; heart;

D O I：

10.1016/S0969-8051(03)00124-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This study evaluates effects of anesthesia on F-18-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：251 / 256

页数：6

共 28 条

[1] Ischemic preconditioning prior to aortic cross-clamping protects high-energy phosphate levels, glucose uptake, and myocyte contractility [J].