Imaging transgenic animals

被引：78

作者：

Budinger, TF ^{[1
]}

Benaron, DA

Koretsky, AP

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Dept Bioengn, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Ctr Funct Imaging, Berkeley, CA 94720 USA

[3] Stanford Univ, Dept Phys, HEPL, Stanford, CA 94305 USA

[4] Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 1999年 / 1卷

关键词：

transgenic; emission imaging; positron emission tomography; single photon tomography; magnetic resonance imaging; optical imaging; magnetic resonance spectroscopy; gene expression;

D O I：

10.1146/annurev.bioeng.1.1.611

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Transgenic and eugenic animals as small as 30 g can be studied noninvasively by radionuclides with resolutions of 1-2 mm, by MRT with resolution of 100 mu m and by light fluorescence and bioluminescence with high sensitivities. The technologies of radionuclide emission, magnetic resonance imaging, magnetic resonance spectroscopy, optical tomography, optical fluorescence and optical bioluminescence are currently being applied to small-animal studies. These technologies and examples of their applications are reviewed in this chapter.

引用

页码：611 / 648

页数：44

共 128 条

[1] MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis
Ahrens, ET
Laidlaw, DH
Readhead, C
Brosnan, CF
Fraser, SE
Jacobs, RE
[J]. MAGNETIC RESONANCE IN MEDICINE, 1998, 40 (01) : 119 - 132
[2] Time-resolved and nonlinear optical imaging for medical applications
Alfano, RR
Demos, SG
Galland, P
Gayen, SK
Guo, YC
Ho, PP
Liang, X
Liu, F
Wang, L
Wang, QZ
Wang, WB
[J]. ADVANCES IN OPTICAL BIOPSY AND OPTICAL MAMMOGRAPHY, 1998, 838 : 14 - 28
[3] Development of central 5-HT2A receptor radioligands for PET: Comparison of [H-3]RP 62203 and [H-3]SR 46349B kinetics in rat brain
Ashworth, S
Hume, SP
Lammertsma, AA
OpackaJuffry, J
Shah, F
Pike, VW
[J]. NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (03) : 245 - 250
[4] Long-term expression of a fluorescent reporter gene via direct injection of plasmid vector into mouse skeletal muscle: Comparison of human creatine kinase and CMV promoter expression levels in vivo
Bartlett, RJ
Secore, SL
Singer, JT
Bodo, M
Sharma, K
Ricordi, C
[J]. CELL TRANSPLANTATION, 1996, 5 (03) : 411 - 419
[5] BENARON DA, 1996, BIOMEDICAL OPTICAL I, P305
[6] THE DESIGN AND PHYSICAL CHARACTERISTICS OF A SMALL ANIMAL POSITRON EMISSION TOMOGRAPH
BLOOMFIELD, PM
RAJESWARAN, S
SPINKS, TJ
HUME, SP
MYERS, R
ASHWORTH, S
CLIFFORD, KM
JONES, WF
BYARS, LG
YOUNG, J
ANDREACO, M
WILLIAMS, CW
LAMMERTSMA, AA
JONES, T
[J]. PHYSICS IN MEDICINE AND BIOLOGY, 1995, 40 (06) : 1105 - 1126
[7] Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography
Boppart, SA
Bouma, BE
Pitris, C
Southern, JF
Brezinski, ME
Fujimoto, JG
[J]. RADIOLOGY, 1998, 208 (01) : 81 - 86
[8] Novel features of Drosophila period transcription revealed by real-time luciferase reporting
Brandes, C
Plautz, JD
Stanewsky, R
Jamison, CF
Straume, M
Wood, KV
Kay, SA
Hall, JC
[J]. NEURON, 1996, 16 (04) : 687 - 692
[9] Optical coherence tomography for optical biopsy - Properties and demonstration of vascular pathology
Brezinski, ME
Tearney, GJ
Bouma, BE
Izatt, JA
Hee, MR
Swanson, EA
Southern, JF
Fujimoto, JG
[J]. CIRCULATION, 1996, 93 (06) : 1206 - 1213
[10] PHOSPHOCREATINE PROTECTS ATP FROM A FRUCTOSE LOAD IN TRANSGENIC MOUSE-LIVER EXPRESSING CREATINE-KINASE
BROSNAN, MJ
CHEN, LH
WHEELER, CE
VANDYKE, TA
KORETSKY, AP
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (06): : C1191 - C1200

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