Physiological targeting to improve anticancer drug selectivity

被引：18

作者：

Hambley, Trevor W. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2008年 / 61卷 / 09期

关键词：

D O I：

10.1071/CH08180

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The physiological differences between solid tumours and the healthy tissues and organs of the body are both an impediment to effective treatment and a potential basis for targeting strategies. In the present review, we outline the physiological features that distinguish tumours including hypoxia, acidity, and inhibited transport and describe the strategies being employed to exploit these differences in order to generate more selective and less toxic anticancer agents.

引用

页码：647 / 653

页数：7

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