Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: An in vitro study

被引：61

作者：

Kah, James Chen Yong ^{[2
]}

Wan, Rachel Cheng Yi ^{[3
]}

Wong, Ker Yi ^{[2
]}

Mhaisalkar, Subodh ^{[3
]}

Sheppard, Colin James Richard ^{[2
]}

Olivo, Malini ^{[1
,4
,5
]}

机构：

[1] Natl Canc Ctr, Div Med Sci, Singapore 169610, Singapore

[2] Natl Univ Singapore, Div Bioengn, Singapore 117574, Singapore

[3] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[4] Inst Biomed Sci, Singapore Bioimaging Consortium, Singapore 138667, Singapore

[5] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

来源：

LASERS IN SURGERY AND MEDICINE | 2008年 / 40卷 / 08期

关键词：

epidermal growth factor receptor (EGFR); gold nanoshells; hypericin; photodynamic therapy (PDT); photothermal therapy (PTT);

D O I：

10.1002/lsm.20674

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm(2) and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.

引用

页码：584 / 589

页数：6

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