Manipulations of core temperatures in ischemia-reperfusion lung injury in rabbits

被引：7

作者：

Chang, Hung ^{[2
]}

Huang, Kun-Lun ^{[3
]}

Li, Min-Hui ^{[4
]}

Hsu, Ching-Wang ^{[1
]}

Tsai, Shih-Hung ^{[1
]}

Chu, Shi-Jye ^{[1
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Emergency Med, Taipei 114, Taiwan

[2] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114, Taiwan

[3] Natl Def Med Ctr, Inst Undersea & Hyperbar Med, Taipei, Taiwan

[4] Natl Def Med Ctr, Inst Aerosp Med, Taipei, Taiwan

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2008年 / 21卷 / 02期

关键词：

Acute lung injury; Hypothermia; Hyperthermia; Ischemia-reperfusion injury;

D O I：

10.1016/j.pupt.2007.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30 min of ischemia followed by 90 min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, K-fC), Delta K-fC, ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia reperfusion in rabbits. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：285 / 291

页数：7

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