In vitro and in vivo characterization of a Tc-99m complex with tris(hydroxymethyl)phosphine (THP)

被引：29

作者：

Berning, DE

Katti, KV

Singh, PR

Higgenbotham, C

Reddy, VS

Volkert, WA

机构：

[1] UNIV MISSOURI,DEPT RADIOL,COLUMBIA,MO 65211

[2] UNIV MISSOURI,DEPT CHEM,COLUMBIA,MO 65211

[3] UNIV MISSOURI,RES REACTOR,COLUMBIA,MO 65211

[4] HARRY S TRUMAN MEM VET HOSP,RES SERV,COLUMBIA,MO 65211

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 05期

关键词：

water-soluble phosphines; technetium; radiopharmaceutical;

D O I：

10.1016/0969-8051(96)00058-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The water-soluble, monophosphine ligand tris(hydroxymethyl)phosphine (THMP) was complexed with Tc-99m, The Tc-99m-THMP was formed in high radiochemical purity by simply mixing (TcO4-)-Tc-99m with THMP over a wide pH range, In vitro and in vivo studies indicated the complex to be highly stable under the respective conditions. HPLC analysis indicated a singular species with a retention time identical to the known [ReO2(THMP)(4)]I complex. Results show that the hydroxymethylphosphine functionality is attractive for use in designing new Tc-99m radiopharmaceuticals.

引用

页码：617 / 622

页数：6

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