Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?

被引：203

作者：

Aggerholm, Anette S. ^{[1
]}

Thulstrup, Ane Marie ^{[1
]}

Toft, Gunnar ^{[1
]}

Ramlau-Hansen, Cecilia H. ^{[1
]}

Bonde, Jens Peter ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Occupat Med, DK-8000 Aarhus, Denmark

来源：

FERTILITY AND STERILITY | 2008年 / 90卷 / 03期

关键词：

obesity; sex hormones; sperm concentration; epidemiology;

D O I：

10.1016/j.fertnstert.2007.07.1292

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. Design: Cross-sectional study. Setting: Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. Patient(s): In total, 2,139 men provided data to the database. Intervention(s): Data on semen and blood samples and information on lifestyle and reproductive factors, including body mass index (BMI), were collected. Main Outcome Measure(s): Semen quality (volume, concentration, total sperm count, and motility) and serum concentration of sex hormones. Result(S): The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E, concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men. Conclusion(s): These results corroborate earlier findings that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.

引用

页码：619 / 626

页数：8

共 28 条

[1] Semen quality and sexual hormones in greenhouse workers [J].

Abell, A ;

Ernst, E ;

Bonde, JP .

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 2000, 26 (06) :492-500

[2] Intra- and inter-individual variability in human sperm concentration, motility and vitality assessment during a workshop involving ten laboratories [J].

Auger, J ;

Eustache, F ;

Ducot, B ;

Blandin, T ;

Daudin, M ;

Diaz, I ;

El Matribi, S ;

Gony, B ;

Keskes, L ;

Kolbezen, M ;

Lamarte, A ;

Lornage, J ;

Nomal, N ;

Pitaval, G ;

Simon, O ;

Virant-Klun, I ;

Spira, A ;

Jouannet, P .

HUMAN REPRODUCTION, 2000, 15 (11) :2360-2368

[3]

Barba C, 2004, LANCET, V363, P157, DOI 10.1016/S0140-6736(03)15268-3

[4] Identifying environmental risk to male reproductive function by occupational sperm studies: Logistics and design options [J].

Bonde, JP ;

Giwercman, A ;

Ernst, E ;

Joffe, M ;

Bisanti, L ;

Vanhoorne, M ;

Thonneau, P ;

Zielhuis, G ;

Kiss, P ;

Abell, A ;

Larsen, SB ;

Danscher, G ;

Kolstad, H ;

Skakkebaek, NE ;

Lindblom, M ;

Taskinen, H ;

Sallmen, M ;

Lahdetie, J ;

Clavert, A ;

Schaller, KH ;

Zschiesche, W ;

Apostoli, P ;

Angotzi, G ;

Lastrucci, L ;

Spano, M ;

Thuis, H ;

Zielhuis, GA ;

deKort, W ;

Heederik, D ;

Baranski, B .

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1996, 53 (08) :511-519

[5] Sperm count and chromatin structure in men exposed to inorganic lead: lowest adverse effect levels [J].

Bonde, JP ;

Joffe, M ;

Apostoli, P ;

Dale, A ;

Kiss, P ;

Spano, M ;

Caruso, F ;

Giwercman, A ;

Bisanti, L ;

Porru, S ;

Vanhoorne, M ;

Comhaire, F ;

Zschiesche, W .

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2002, 59 (04) :234-242

[6] Relation between semen quality and fertility:: a population-based study of 430 first-pregnancy planners [J].

Bonde, JPE ;

Ernst, E ;

Jensen, TK ;

Hjollund, NHI ;

Kolstad, H ;

Henriksen, TB ;

Scheike, T ;

Giwercman, A ;

Olsen, J ;

Skakkebæk, NE .

LANCET, 1998, 352 (9135) :1172-1177

[7] EVIDENCE FOR DECREASING QUALITY OF SEMEN DURING PAST 50 YEARS [J].

CARLSEN, E ;

GIWERCMAN, A ;

KEIDING, N ;

SKAKKEBAEK, NE .

BRITISH MEDICAL JOURNAL, 1992, 305 (6854) :609-613

[8]

Diamanti-Kandarakis E, 2001, Obes Rev, V2, P231, DOI 10.1046/j.1467-789X.2001.00041.x

[9] Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene [J].

Farooqi, IS ;

Keogh, JM ;

Yeo, GSH ;

Lank, EJ ;

Cheetham, T ;

O'Rahilly, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1085-1095

[10] Obesity: The worldwide epidemic [J].

James, PT .

CLINICS IN DERMATOLOGY, 2004, 22 (04) :276-280

← 1 2 3 →