Novel approach to the synthesis of the aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4-OHA)

被引：21

作者：

daSilva, EJT ^{[1
]}

Melo, MLSE ^{[1
]}

Neves, ASC ^{[1
]}

机构：

[1] UNIV COIMBRA,FAC FARM,QUIM FARMACEUT LAB,CTR ESTUDOS FARMACEUT,P-3000 COIMBRA,PORTUGAL

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 14期

关键词：

D O I：

10.1039/p19960001649

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward synthesis of the title compound is achieved through a novel approach, comprising the oxidation of the easily available 5 alpha-androst-3-en-17-one 1 in two sequential steps to yield the kinetic diosphenol 4, which gives the desired 4-OHA 5 by base-catalysed isomerization.

引用

页码：1649 / 1650

页数：2

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