Endothelial progenitor cells and their potential clinical applications in peripheral arterial disease

被引：16

作者：

Alobaid, N

Alnaeb, ME

Sales, KM

Seifalian, AM ^{[1
]}

Mikhailidis, DP

Hamilton, G

机构：

[1] UCL, Acad Div Surg & Intervent Sci, Biomat & Tissue Engn Ctr, London NW3 2PF, England

[2] Royal Free Hampstead NHS Trust Hosp, Vasc Unit, London, England

[3] UCL, Dept Clin Biochem, London NW3 2PF, England

来源：

ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH | 2005年 / 12卷 / 5-6期

关键词：

angiogenesis; bypass graft; endothelial progenitor cells; endothelium; peripheral arterial disease; tissue engineering;

D O I：

10.1080/10623320500476617

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial progenitor cells (EPCs) were originally thought to be present only during embryonic development. New evidence suggests that they can persist into adult life, circulate in the peripheral blood and may play an important part in endothelial repair and replacement of dysfunctional endothelium. They may also play a role in the formation of new blood vessels ( angiogenesis, vasculogenesis, and arteriogenesis) in ischemic tissues. In addition, EPCs have the potential to endothelialize small-diameter prosthetic vascular bypass grafts and generate a nonthrombogenic surface, thereby increasing the patency rate of these grafts. EPCs may also be used in the clinical assessment of risk of vascular disease. In this review, the authors discuss the potential use of EPCs in the management of peripheral arterial disease (PAD).

引用

页码：243 / 250

页数：8

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[21] EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND STEM-CELL FACTOR, ALONE AND IN COMBINATION, ON THE MOBILIZATION OF PERIPHERAL-BLOOD CELLS THAT ENGRAFT LETHALLY IRRADIATED DOGS [J].