Formation and fate of platelet microparticles

被引：128

作者：

Flaumenhaft, R ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Hemostasis & Thrombosis, Boston, MA 02115 USA

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2006年 / 36卷 / 02期

关键词：

platelet; microparticle; phosphatidylinositol 4,5-bisphosphate (PIP2); megakaryocyte; clearance; complement;

D O I：

10.1016/j.bcmd.2005.12.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is increasing evidence that platelet microparticles participate in thrombus formation. Yet the origin of platelet microparticles and their fate in the circulation remain poorly defined. It is unknown, for example, whether circulating platelet microparticles found in healthy individuals are derived from activated platelets or generated during megakaryopoiesis. The life span of platelet microparticles and the mechanism of their clearance have also not been determined. This article addresses these fundamental aspects of the physiology of platelet microparticles. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：182 / 187

页数：6

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