Antimicrobial activity of some 13-alkyl substituted protoberberinium salts

被引：76

作者：

Iwasa, K

Kamigauchi, M

Sugiura, M

Nanba, H

机构：

[1] Kobe Pharmaceutical University, Higashinada, Kobe 658, 4-19-1, Motoyamakita

来源：

PLANTA MEDICA | 1997年 / 63卷 / 03期

关键词：

13-alkylprotoberinium salts; antimicrobial activity; antifungal activity;

D O I：

10.1055/s-2006-957651

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against SZ) as kanamycin sulfate. 13-hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.

引用

页码：196 / 198

页数：3