Antimicrobial activity of some 13-alkyl substituted protoberberinium salts

被引:76
作者
Iwasa, K
Kamigauchi, M
Sugiura, M
Nanba, H
机构
[1] Kobe Pharmaceutical University, Higashinada, Kobe 658, 4-19-1, Motoyamakita
关键词
13-alkylprotoberinium salts; antimicrobial activity; antifungal activity;
D O I
10.1055/s-2006-957651
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against SZ) as kanamycin sulfate. 13-hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.
引用
收藏
页码:196 / 198
页数:3
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