Hepatitis E virus infection in wild mongooses of Okinawa, Japan: Demonstration of anti-HEV antibodies and a full-genome nucleotide sequence

被引：121

作者：

Nakamura, M

Takahashi, K

Taira, K

Taira, M

Ohno, A

Sakugawa, H

Arai, M

Mishiro, S

机构：

[1] Toshiba Gen Hosp, Dept Med Sci, Shinagawa Ku, Tokyo 1408522, Japan

[2] Meat Hyg Inspect Ctr, Pharmaceut Affairs & Sanitat Div, Dept Hlth & Welf, Okinawa 9011202, Japan

[3] Okinawa Prefectural Inst Hlth & Environm, Microbiol Sect, Okinawa 9011202, Japan

[4] Univ Ryukyus, Sch Med, Transfus Sect, Okinawa 9030215, Japan

来源：

HEPATOLOGY RESEARCH | 2006年 / 34卷 / 03期

关键词：

hepatitis E virus (HEV); single-stranded RNA virus; zoonosis; interspecies transmission; mongoose;

D O I：

10.1016/j.hepres.2005.10.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis E virus (HEV), a single-strand RNA virus, has been recovered not only from human beings but also from various species of animals. Here we report our results suggesting that mongoose should be added to the list of reservoir animals of HEV. Of 100 mongooses we examined in Okinawa, Japan, 21 were thought to be positive for anti-HEV antibodies, among which one was definitely positive for HEV RNA. Full-genome sequencing of the HEV isolate revealed that it segregates to a unique subgroup within genotype III. Interestingly, this mongoose strain was closely related to a swine isolate previously reported from Okinawa, implicating the possibility of interspecies transmission between these animals. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：137 / 140

页数：4

共 14 条

[11] Full-genome nucleotide sequence of a hepatitis E virus strain that may be indigenous to Japan [J].