Catalytic, asymmetric Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives.: Efficient synthesis of a novel inhibitor of ceramide trafficking, HPA-12

被引：87

作者：

Kobayashi, S ^{[1
]}

Matsubara, R ^{[1
]}

Kitagawa, H ^{[1
]}

机构：

[1] Univ Tokyo, CREST, Grad Sch Pharmaceut Sci, Japan Sci & Technol Corp,Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 01期

关键词：

D O I：

10.1021/ol017062u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS Catalytic, enantioselective Mannich-type reactions of N-acylimino esters for direct formation of N-acylated amino acid derivatives are described. A chiral copper catalyst prepared from Cu(OTf)(2) and a chiral diamine ligand is used. A novel inhibitor of ceramide trafficking, HPA-12, is efficiently synthesized using this reaction.

引用

页码：143 / 145

页数：3

共 58 条

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